Recovery in feces after oral administration of Lactobacillus casei subsp. casei I-1572 CNCM (L. casei DG), recently proposed as a probiotic strain, was studied. The strain was given to 12 healthy human volunteers for 7 days as a water-soluble preparation, at a daily dose 8.5x109 CFU. Fecal samples were collected before, during and after consumption. The strain was identiﬁed by the characteristic colony morphology and biochemical pattern. L. casei DG was found in the feces of all volunteers during the administration period and 7 days after the last dose. The strain was also detectable in 8/12 volunteers 14 days after administration. No eﬀects were observed on the number of total fecal lactobacilli. Similar results were observed in a parallel animal study on germ-free mice. The study showed that L. casei DG was able to remain in the intestinal tract for more than a week after discontinuation of consumption.
Drago L, De Vecchi E, Valli M, Nicola L, Lomabardi A and Gismondo MR
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