The antimicrobial role of probiotic Lactobacillus casei subspecies casei DG (L. casei DG) and of the mix culture of probiotic Lactobacillus acidophilus LA-5 and Biﬁdobacterium BB-12 was tested on species of Staphylococcus, Streptococcus, Pasteurella, and Neisseria genera from supragingival sites from dogs with dental disease of diﬀerent breed, age, sex, weight, and diet. The research was conducted on these four genera because of their importance in zoonotic infections after dog bites.
Species from Staphylococcus, Streptococcus, Pasteurella, and Neisseria genera were isolated and identiﬁed. To test the antimicrobial eﬃcacy of L. casei DG and the mixed culture of probiotic L. acidophilus LA-5 and Biﬁdobacterium biﬁdum BB-12 on the pathogenic species, the agar overlay method was used.
L. casei DG had a bactericidal eﬀect on all analyzed species isolated from Staphylococcus, Streptococcus, Pasteurella, and Neisseria genera after 24 hours of incubation. The mixed probiotic culture made up of L. acidophilus LA-5 and Biﬁdobacterium BB-12 species had no bactericidal eﬀect on the species of Staphylococcus and Streptococcus genera, which were resistant. However, it had a bacteriostatic eﬀect on several species of Pasteurella and Neisseria genera.
This work highlights the antimicrobial potential of probiotics in vitro, demonstrating that the probiotic L. casei DG has a bactericidal eﬀect on all analyzed species isolated from dental plaque and that the mix culture of probiotic L. acidophilus LA-5 and Biﬁdobacterium BB-12 has only a bacteriostatic eﬀect.
Zambori C, Morvay AA, Sala C, Licker M, Gurban C, Tanasie G, Tirziu E
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